What is HCG?

Many patients are calling us asking "Where can I get HcG? We can help. NovaGenix offers physician consultations for patients looking to start or continue HcG therapy while on TRT.

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Human Chorionic Gonadotropin for Patients on Testosterone Replacement

HCG (Human Chorionic Gonadotropin) is often called the pregnancy hormone due to the fact that it’s made by cells formed in the placenta, which provides nutrients to the egg after it’s been fertilized and attaches to the wall of the uterus. HcG levels may first be detected in a blood test around 11 days after conception and approximately 12-14 days after conception if taking a urine test. HCG is an FDA-approved medication that may help treat specific conditions for both men and women. For men, it plays an important role in TRT.

What is HcG used for in men?

For many male patients, hcg may be prescribed to help treat the symptoms of hypogonadism often called low T or Male Andropause. It can also be used to treat infertility. HcG works to increase the males natural production of testosterone in the testes and increases the production of sperm.

Human chorionic gonadotropin is a hormone that’s composed of 2 subunits. An α and a β-subunit. hCG and Luteinizing hormone, or LH, both share an identical α-subunit. hCG if different from LH because of the fact that its β-subunit with a 24 amino acid tail. This 24 amino acid side chain helps to increases the receptor activity and will slow the metabolism of hCG in the body. HcG has a half life that is approximately 36 hours compared to 30 minutes for Luteinizing Hormone. Because they both share the same receptor, have increased receptor activity, and have a much longer half, life, hcg is the best pharmacological analog to LH.

HCG injections are frequently prescribed to men with testosterone deficiency. Normal ranges of testosterone in men are often 250 to 1100 Ng/dl or nanograms per deciliter. With suboptimal testosterone levels and the physical/emotional symptoms of low testosterone, a physician may be able to diagnose a patient and treat them for hypogonadism.

These symptoms may include:

Constantly feeling tired and fatigued
Internalizing and feeling greater levels of stress
Low “Drive” and lack of romantic interest
Depression
Anxiety
Lack of confidence
Increased Body fat
Decreased muscle mass
Poor sleep quality

The American Urological Association recommends, hCG for patients who have been diagnosed with testosterone deficiency and that also desire to maintain fertility and natural testosterone production.

HcG injections can help increase testosterone levels in men, as well as increase fertility, “romantic drive” and increase the size of the testes, which is important for patients on TRT who may experience atrophy, or “shrinkage” as its called. It helps increase the effectiveness of testosterone therapy by helping maintain stable levels, natural production and prevents some side effects associated with testosterone injections.

How does it work to increase testosterone?

In men, hCG acts as a luteinizing hormone (LH) analog. LH stimulates the Leydig cells which are located in the testicles. This then results in the production of testosterone within the testes, keeping natural production working and preventing testicular shrinkage. LH also will stimulate the production of sperm within the seminiferous tubules of the testes and as both testosterone and sperm are being produced, the testicles will maintain their size for patients on TRT.