PT-141 Therapy at NovaGenix Health & Wellness

PT-141 (Bremelanotide): Advanced Peptide Therapy for Libido and Arousal Support

PT-141 Peptide Therapy for Sexual Health, Arousal, and Performance

From Peptide Innovation to Enhanced Sexual Wellness & Confidence

Struggling with low libido, reduced sexual desire, or performance concerns that don’t improve with the usual options? You’re not alone—and it’s more common than most people realize. At NovaGenix Health & Wellness, we offer PT-141 peptide therapy (also known as Bremelanotide) as an advanced, physician-guided option prescribed and monitored by Dr. Timothy W. Mackey to help support sexual wellness for both men and women.

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What Is PT-141? (And Why Are Patients Asking About It?)

PT-141 is a peptide therapy designed to help improve sexual desire and arousal through a unique mechanism that differs from medications like sildenafil (Viagra) or tadalafil (Cialis). Instead of primarily targeting blood flow, PT-141 is known for working through the central nervous system—helping stimulate the brain pathways involved in libido and arousal.

Think of PT-141 as a desire-support peptide—it helps activate the “signal” for arousal, which can be especially helpful when low desire is the bigger issue than performance alone. Many women who experience sexual arousal disorders, sometimes called hypoactive sexual desire disorder or low sex drive have had success with this peptide.

A persistent decline or loss of sexual desire can create significant personal stress and strain on intimate relationships. PT-141 is an innovative peptide designed to support sexual health in women by targeting desire and arousal pathways in the brain. It mimics the action of the hormone α-MSH (alpha-melanocyte-stimulating hormone and unlike traditional treatments, PT-141 works centrally rather than through blood flow. In many patients it has helped improve low libido and female sexual arousal disorder and helps men with erectile dysfunction (ED). By acting on the central nervous system rather than directly on blood vessels, it enhances neural signaling involved in sexual response and may support the ability to achieve and maintain erections.

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How PT-141 Works in the Body

PT-141 is a melanocortin receptor agonist, meaning it activates specific receptors in the brain involved in sexual function and desire. It is commonly administered via subcutaneous injection or nasal spray under medical guidance.

Because it acts centrally, PT-141 is often discussed for people who:

• Feel a drop in libido even when blood flow is not the main issue
• Don’t respond well to traditional ED medications
• Want a therapy that supports both arousal and desire

Many patients appreciate that PT-141 may help support sexual function without requiring precise “timing” right before intimacy, since the goal is to improve desire and responsiveness, not just mechanics.

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What Can PT-141 Help With?

Patients commonly ask about PT-141 for support with:

• Low sex drive / low libido
• Reduced arousal or “lack of interest”
• Erectile dysfunction that doesn’t fully respond to PDE5 medications
• Sexual confidence concerns tied to desire and performance
• Sexual wellness support during hormone optimization or aging

While results vary, PT-141 is often used as part of a comprehensive plan, especially when libido and arousal are the primary concerns.

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How Is PT-141 Prescribed at NovaGenix?

At NovaGenix, PT-141 is prescribed only after a medical consultation with Dr. Mackey. Your plan is customized based on:

• Symptoms and goals
• Medical history and current medications
• Hormone status (testosterone, estrogen, thyroid, etc.)
• Overall cardiovascular and metabolic health

PT-141 is most commonly used as a subcutaneous (SQ) injection, which many patients can learn to administer at home after proper instruction. For patients who qualify, our U.S.-based partner pharmacies can dispense and ship medications directly to your door, making the process convenient and private and safer than trying to buy medication from an uncertified or licensed online overseas pharmacy.

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Is PT-141 Right for You?

PT-141 may be a good option if you:

• Have low libido that feels out of character
• Want a desire-focused option beyond standard ED medications
• Suspect stress, hormones, or aging are affecting sexual wellness
• Want physician-guided support instead of trial-and-error solutions

The best way to find out is through a one-on-one consultation with an experienced physician who understands both peptide therapy and hormone optimization. Speaking with a healthcare provider will let you know what the best option for each patient after discussing goals, medical history and review the pros and cons of all options.

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Why Choose NovaGenix for PT-141 & Peptide Therapy?

At NovaGenix Health & Wellness, we take a medical-first, evidence-guided approach:

• Physician-led care with Dr. Timothy W. Mackey, DO
• Personalized treatment protocols (no cookie-cutter programs)
• Experience in men’s health, women’s wellness, TRT/HRT, and peptides
• Ongoing education, monitoring, and support
• Trusted U.S.-based partner pharmacies

Your care is designed around you, your goals, your lifestyle, and your health history.

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Meet Dr. Timothy W. Mackey

Your Expert in Hormone, Peptide & Wellness Care

Dr. Mackey is a licensed Doctor of Osteopathic Medicine with extensive experience in internal medicine, hormone replacement therapy, peptide therapy, and anti-aging medicine. With a background that includes service in the U.S. Army, he brings a disciplined, evidence-based, and patient-centered approach to care.

Certified in bio-identical hormone replacement and anti-aging medicine, Dr. Mackey helps patients optimize vitality, confidence, and long-term wellness safely and responsibly.

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Ready to Learn More About PT-141?

If you’re interested in learning whether PT-141 peptide therapy may support your sexual wellness goals, we’re here to help.

👉 Schedule your FREE initial consultation with Dr. Mackey today
👉 Fill out our New Patient Intake Form and our team will contact you to schedule your telemedicine visit

At NovaGenix Health & Wellness, we help you feel confident, connected, and in control—so you can live better.

Visit NovaGenix Health & Wellness on Facebook and give us a follow!

Here are five scholarly sources about PT-141 (Bremelanotide) webpage — with direct links to peer-reviewed research or clinical trial summaries:

1. Molinoff PB et al. – PT-141 and Sexual Function
   Clinical evidence showing PT-141 increases erectile activity in humans and animal models.
   https://pubmed.ncbi.nlm.nih.gov/12851303/
2. Kingsberg SA et al. – Bremelanotide for Hypoactive Sexual Desire Disorder (Phase 3 Trials)
   Two randomized, placebo-controlled clinical trials showing improvements in sexual desire and related distress with bremelanotide.
   https://pmc.ncbi.nlm.nih.gov/articles/PMC6819021/
3. Simon JA et al. – Long-Term Safety and Efficacy of Bremelanotide
   Extension of phase 3 studies demonstrating sustained efficacy and safety over 52 weeks.
   https://pmc.ncbi.nlm.nih.gov/articles/PMC6819023/
4. Mayer D et al. – Bremelanotide Review
   Peer-reviewed article summarizing clinical data on bremelanotide and its approval for hypoactive sexual desire disorder.
   https://pubmed.ncbi.nlm.nih.gov/31893927/
5. Safarinejad MR – Bremelanotide in Erectile Dysfunction Patients
   Randomized controlled trial evaluating bremelanotide as a treatment option in ED, including those not responsive to PDE-5 inhibitors.
   https://pubmed.ncbi.nlm.nih.gov/18206919/

BPC-157 Therapy at NovaGenix Health & Wellness

From Regenerative Peptides to Advanced Recovery Support

Struggling with lingering joint pain, slow healing, gut issues, or nagging injuries that just won’t resolve? At NovaGenix Health & Wellness, we’re proud to offer BPC-157 peptide therapy, a cutting-edge regenerative option prescribed and monitored by Dr. Timothy W. Mackey to help support healing from the inside out.

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What Is BPC-157? (And Why Are So Many Patients Asking About It?)

BPC-157 stands for Body Protection Compound-157. It’s a pentadecapeptide derived from a naturally occurring protein in the human stomach. Its 15–amino-acid structure is what gives it stability and regenerative potential in research settings.

In short, pentadecapeptides are small but powerful biological messengers used in advanced and regenerative medicine research. Researchers have been studying BPC-157 for its unique ability to support tissue repair, inflammation control, and cellular healing across multiple systems in the body.

Think of BPC-157 as a signal peptide…it helps tell your body where healing is needed and supports the repair process at a cellular level.

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How BPC-157 Works in the Body

BPC-157 interacts with several key biological pathways involved in recovery and regeneration. Literature from an orthopedic sports medicine shows the potential for BPC becoming more prevalent in medical use as it’s starting to become a popular option for those suffering sports related injuries. Preclinical research has demonstrated promising potential for supporting the healing of musculoskeletal injuries, including fractures, tendon and ligament damage, and muscle injuries. While it is not approved by the U.S. Food and Drug Administration and is prohibited in professional sports, interest in its use has grown, particularly among clinicians and active individuals seeking advanced recovery support for the following conditions:

• Tissue Repair Support – Encourages healing of tendons, ligaments, muscles, and joints
• Anti-Inflammatory Effects – Helps regulate inflammatory responses without suppressing normal healing
• Angiogenesis Support – Promotes healthy blood vessel formation to injured tissue
• Gut & GI Support – Originally studied for its protective effects on the digestive tract
• Neurological Support – May help protect nerve tissue during recovery

Because of these mechanisms, BPC-157 is often discussed in regenerative medicine and sports-recovery research.

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What Can BPC-157 Help With?

Patients commonly inquire about BPC-157 for support with:

• Joint pain and stiffness
• Tendon or ligament injuries
• Muscle strains or tears
• Post-surgical recovery
• Chronic inflammation
• Gut irritation or digestive issues
• Slow healing from workouts or injuries

While BPC-157 is not a replacement for medical treatment or surgery, many patients use it as part of a comprehensive wellness and recovery plan.

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How Is BPC-157 Prescribed at NovaGenix?

At NovaGenix, BPC-157 is prescribed only after a medical consultation with Dr. Mackey. Treatment plans are personalized based on your health history, goals, and current symptoms.

Most patients use BPC-157 as a subcutaneous (SQ) injection, which allows for consistent absorption and targeted systemic support. After proper instruction, some patients may be eligible for at-home administration. Another popular option for patients is BPC-157 capsules that can be taken by mouth, so be sure to talk to Dr. Mackey about the best delivery method for you.

For patients who qualify, our partner pharmacies can dispense and ship medications directly to your door, making treatment convenient and streamlined.

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Is BPC-157 Right for You?

BPC-157 may be a good option if you:

• Feel stuck in recovery despite rest or physical therapy
• Want to support healing without traditional pain medications
• Are active, athletic, or dealing with chronic joint or tendon issues
• Are interested in regenerative or peptide-based therapies

The best way to know is through a one-on-one consultation with an experienced physician who understands peptide therapy.

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Why Choose NovaGenix for Peptide Therapy?

At NovaGenix Health & Wellness, we take a medical-first, evidence-guided approach to advanced therapies:

• Physician-led care with Dr. Timothy W. Mackey, DO
• Personalized treatment protocols
• Experience in hormone optimization, regenerative medicine, and wellness
• Ongoing monitoring and patient education
• Trusted U.S.-based partner pharmacies

We don’t offer cookie-cutter programs—your care is designed around you.

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Meet Dr. Timothy Wray Mackey

Your Expert in Hormone, Peptide & Wellness Care

Dr. Mackey is a licensed Doctor of Osteopathic Medicine with extensive experience in internal medicine, hormone replacement therapy, peptide therapy, and anti-aging medicine. With a background that includes service in the U.S. Army, he brings a disciplined, evidence-based, and patient-centered approach to care.

Certified in bio-identical hormone replacement and anti-aging medicine, Dr. Mackey helps patients optimize healing, performance, and long-term wellness safely and responsibly.

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Ready to Learn More About BPC-157?

If you’re interested in learning whether BPC-157 peptide therapy may support your recovery and wellness goals, we’re here to help.

👉 Schedule your FREE initial consultation with Dr. Mackey today
👉 Fill out our New Patient Intake Form and our team will contact you to schedule your telemedicine visit

At NovaGenix Health & Wellness, we help you heal smarter, so you can move, feel, and live better.

Visit NovaGenix Health and Wellness on Facebook and gives us a follow!

Here are several peer-reviewed scholarly sources on BPC-157 with direct links for reference:

1. Emerging Use of BPC-157 in Orthopaedic Sports Medicine – Systematic review showing preclinical outcomes in muscle, tendon, ligament, and bone healing models. Emerging Use of BPC‑157 in Orthopaedic Sports Medicine (systematic review)

2. Regeneration or Risk? A Narrative Review of BPC-157 – Discusses tendon healing, muscle recovery, and limitations of animal studies. Regeneration or Risk? A Narrative Review of BPC‑157

3. Pentadecapeptide BPC 157 Enhances Tendon Fibroblast Growth – Early study showing accelerated tendon fibroblast migration and outgrowth in vitro. The Promoting Effect of Pentadecapeptide BPC 157 on Tendon Healing (Journal of Applied Physiology)

4. Preclinical Safety Evaluation of BPC-157 – Toxicity research in animals reporting protective activity with no significant adverse effects. Preclinical Safety Evaluation of BPC‑157 (Regulatory Toxicology and Pharmacology)

5. BPC-157 in Tendon & Ligament Healing Models – Systematic review indicating enhanced connective tissue healing in animal research. Application of Peptide Therapy for Ligaments and Tendons (ScienceDirect)

6. Muscle Healing Effects of BPC-157 – Animal model study showing improved muscle recovery even under corticosteroid impairment. Impact of Pentadecapeptide BPC‑157 on Muscle Healing (Med Sci Monit)

7. Wikipedia – BPC-157 Entry – Overview of basic peptide properties, mechanisms, and research context including musculoskeletal effects. BPC‑157 (Wikipedia)

Important Notes:

• Most of the evidence supporting BPC-157’s healing effects comes from preclinical animal studies, not large human clinical trials.

• Human safety, efficacy, and approved medical uses are still not well established. 

Low Testosterone in Winter: How Seasonal Changes Impact Men’s Energy, Mood, and Metabolism

Winter Low Testosterone in Men Over 40: How to Restore Energy, Strength, and Hormonal Balance

Struggling Through Winter After 40? Testosterone, Sleep, and Stress May Be the Cause

Winter can be one of the most challenging seasons for men’s health, especially for men over 40. Depending on where you live, the winter brings shorter days, reduced sunlight, colder weather, and post-holiday stress which often lead to fatigue, weight gain, low motivation, and declining physical performance. Often when men go to their doctors and explain these signs and symptoms, many primary care physicians tell the patient that the reason is aging, stress or seasonal burnout and while all along the major contributor was low testosterone. It is often a key underlying factor in many health and lifestyle issues and yet many doctors don’t/won’t even test for it, despite its importance in men’s health.

At NovaGenix Health & Wellness, we’ve been treating men in the Jupiter, Florida area for over a decade and we’ve seen a noticeable increase in men seeking hormone evaluations during the winter months. Understanding how seasonal changes impact testosterone, stress hormones, and metabolism is an important first step toward restoring energy and vitality.

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Why Testosterone Levels Drop During the Winter

Testosterone levels naturally decline with age—typically beginning around the mid-twenties to thirties at a rate of 1–2% per year. By the time men reach their 40s and 50s, enough time has gone by that you finally notice that decline due to the unwanted effects from Low T. Winter conditions can further compound the issue along with other sources of stress, sleep, diet, etc...

Reduced sunlight hours  lead to lower vitamin D levels, which play a direct role in testosterone production and mood regulation. Shorter days can also disrupt circadian rhythms, contributing to poor sleep quality and elevated cortisol (the body’s primary stress hormone). Over time, this hormonal imbalance can accelerate fat gain, muscle loss, and fatigue. In one study, “Seasonal Variation in Testosterone Levels in Northern Norway” (Svartberg et al., Journal of Clinical Endocrinology & Metabolism)

In this large study on men, test subjects were evaluated based on exposure to extreme seasonal light variation and found patterns in their testosterone levels.

“Total testosterone showed a bimodal seasonal variation… with the lowest levels in summer and free testosterone peaking in December… the results persisted after adjusting for age and waist-to-hip ratio.”

Many people will gain weight this time of year and some people refer to this as “Winter Weight.”

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Common Winter Symptoms of Low Testosterone

Men experiencing low testosterone during winter often report:

• Persistent fatigue or low or lack of energy
• Increased abdominal/belly fat
• Difficulty building or maintaining muscle mass
• Brain fog, forgetfulness or reduced focus
• Decreased motivation in work and at home
• Lower libido or sexual performance including ED
• Mood changes, grumpiness or irritability

Because these symptoms develop gradually over time, many men assume they are simply part of aging or seasonal stress, delaying proper diagnosis and treatment. In some cases, they just seemed to have gotten used to it.

In a separate study titled “Seasonal Variation in Serum Testosterone Levels” (Demir et al.) researchers examined the impact of cold seasons and came to interesting conclusions. They specifically stated that…  

“Although testosterone levels are within normal limits in both seasons, the level in cold months is lower than in hot months… The impact of cold seasons in particular should be taken into account when evaluating testosterone levels and sexual status.”

 

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How Hormonal Imbalance Affects Metabolism and Mood

Testosterone is a vital human hormone but ESPECIALLY important for men. It plays a critical role in building and maintaining lean muscle mass while regulating fat metabolism. It simultaneously supports healthy bone density and is important in helping sustain mental clarity. When a man’s testosterone levels fall, his body becomes more efficient at storing fat and less efficient at building muscle.

Work and life aren’t always easy. It’s a well-established fact that chronic stress raises cortisol levels. We also know that elevated cortisol levels will suppress testosterone production as well as promote accumulation and increase in belly fat, while also disrupting blood sugar regulation. This creates a cycle that becomes harder to reverse during winter months.

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Winter Hormone Optimization Strategies for Men

1. Make Resistance Training a Priority

Strength training is far and away one of the best and most effective natural ways to support testosterone levels in men. Ideally you can focus on compound/full body movements like squats, deadlifts, presses, and rows, three to four times per week for really good results.  Resistance training helps counteract winter muscle loss and metabolic slowdown. Studies have shown that strength training activates large muscle groups and will increase anabolic hormone signaling. Over time, consistent strength training helps maintain higher baseline testosterone levels while also improving muscle mass, metabolism, and overall hormonal balance in men.

A comprehensive review of research on resistance training in men and the effect on hormones reported that testosterone concentrations are generally elevated directly following heavy resistance exercise in men. This acute hormonal surge occurs after workouts that include high volume and heavy loads.  In a controlled study titled “Effect of testosterone on muscle mass and muscle protein synthesis” it found that testosterone administration in men increased the rate of protein synthesis in muscle by approximately 27% compared to baseline measurements, which indicates that testosterone directly promotes the processes needed on a cellular level for both the building and maintaining of muscle tissue. 

2. Try to Maintain a Healthy Body Composition All-Year

Don’t put yourself into a negative cycle. Excess body fat in men will increase aromatase activity. That means your body will make for estrogen. Excess body fat will release an enzyme that converts testosterone into estrogen. That’s not great when you’re trying to get stronger and maintain muscle mass. By maintaining a healthy body composition with lean muscle mass throughout the year, it will help preserve hormonal balance and support overall metabolic health. If you let yourself get a little too “soft”, so to speak, the climb out of that can become more difficult and your hormones start to work against you.  In the published study titled “Percent body fat was negatively correlated with Testosterone levels in male” the authors analyzed data from the National Health and Nutrition Examination Survey (NHANES), a large population study and found that a “…significant inverse relationship between body fat percentage and testosterone levels in adult males. Specifically, higher total body fat was associated with lower serum testosterone (β = −11.97, P < 0.0001),” meaning that as adiposity (fat) increases, testosterone concentrations in men will drop significantly.

3. Fix Your Diet and Support Key Nutrients

The human body grows and supports itself on a molecular and cellular level from the food and nutrients we eat. Essential to hormonal health is Zinc and magnesium. These 2 minerals are essential for testosterone synthesis. Foods that are rich in zinc include things like oysters, red meat, pumpkin seeds, and legumes like lentils, chickpeas, and black beans. Magnesium, however, can be found in other foods like leafy greens, nuts, avocados, and even dark chocolate. During winter months, vitamin D3 supplementation is often helpful because of a decrease in sun exposure.

4. Consider TRT/Medical Testosterone Therapy

For whatever reason, lifestyle changes may not be enough to raise hormone levels adequately and symptoms can persist in some men. This may be a good time to think about medical testosterone replacement therapy (TRT). A doctor will be needed to help determine whether hormone therapy may be appropriate. Proper TRT is based on comprehensive lab testing and ongoing medical monitoring, not guesswork so an experienced physician in this specific field is needed.

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The Secret Weapon. Sleep: A Critical Factor in Winter Testosterone Levels

Sleep is of significant importance for hormone production in both men and women.  For the guys, testosterone and human growth hormone are primarily released during deep and REM sleep. In a controlled study of adult men titled “Disruption of the Nocturnal Testosterone Rhythm by Sleep Fragmentation in Normal Men”, plasma testosterone was found to rise upon falling asleep and reached peak levels at about the time of the first REM sleep episode, remaining elevated throughout the night until waking.  

Its important to get enough uninterrupted sleep to maximize testosterone production and utilization and cellular uptake. It was determined that interrupted/fragmented sleep caused a significant delay in the increase in testosterone during the night, when it replenishes itself the most (03:24 h ± 1:13 vs. 22:35 h ± 0:22).

What this means is that poor sleep quality, which may be common during winter for some people, can significantly lower testosterone levels while at the same time increase their cortisol levels.

Taking efforts to improve sleep quality, routines and doing things like maintaining a cool bedroom environment, limit the amount of evening screen exposure to experience and address hormonal imbalances can dramatically help to improve both recovery and improve energy levels.

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Limit Your Stress Levels. Protecting Both Testosterone and Overall Health

Stress is a silent killer. Chronic stress is one of the most underestimated contributors to low t in men. Elevated cortisol levels will over time lead to other medical issues like increased fat storage, high blood pressure, reduced immune functioning, and accelerated aging which will all contribute to a negative downward cycle that’s tough to get out of.

Trying to implement a few simple daily practices such as walking, stretching, meditation, or controlled breathing can all help lower cortisol and can improve mood, energy, motivation and more. Consistency is what matters more than something like duration, especially during winter when activity levels tend to drop. You don’t have to do 3 hours every day but if you can remain a somewhat regular schedule, you’ll have a better chance of seeing results.  Stress will  hormones influence many serum hormone levels and may also alter the clinical status of several preexisting disorders in the endocrine system.

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Winter Nutrition for Hormone and Immune Support

Winter diets tend to be hearty and rich and can make or break a new year’s resolution.  A healthy diet will support hormone production and immune resilience in people. Focus on nutrient dense whole foods. Diets that are balanced with foods high in omega-3 fatty acids, protein, vitamin D, Zinc and Magnesium, as well fiber-rich vegetables and legumes will help optimize endocrine production. Limiting things like processed sugars and alcohol is especially important during winter, as both will disrupt testosterone production, balance and sleep quality making them hormone killers.

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Support Men’s Health Year-Round

Winter doesn’t have to be a season of decline for men. By addressing things like hormonal balance, sleep quality, stress levels, and nutrition, men can maintain the way they look and feel without a decline in strength, energy, and mental clarity well into the colder months.

Understanding what’s happening inside of your body is quite often the first step forward towards restoring both vitality and long-term health in men, no matter the season.

For anyone interested in learning more, NovaGenix Health & Wellness offers physician-guided expertise in testosterone replacement therapy and men’s health, providing individualized evaluations to help men better understand their hormones, energy, and overall metabolic health.

Why Winter Weight Loss Isn’t About Willpower: The Hormones Quietly Working Against You

Why “Motivation” Fails in The Winter: The Hormone Factors That Block Weight Loss (and What Actually Helps)

It happens every year. Each January, motivation is everywhere you look. Gym memberships skyrocket, diets and meal plans are reset, and promises are made to countless mirrors and scales to “finally get healthy.” Yet the actual truth for many people is that the enthusiasm and momentum fades quickly, soon replaced by frustration and self-blame. When weight loss stalls, it’s often labeled as a motivation problem—but in reality, biology usually throws a bigger hurdle at us. It’s Hormones. Especially after the holidays. These can quietly block progress no matter how strong someone’s resolve is or how hard they try to lose unwanted weight.

One of the most influential hormones regarding weight is insulin. It helps regulate blood sugar and fat storage in the body. Holiday eating patterns tend to include indulgence at parties with frequent sugar and deserts, refined carbohydrates, and late-night meals are all things that keep insulin levels elevated. When insulin levels stay high, the body struggles to release stored fat. By cutting calories in January without addressing insulin can often lead to constant hunger, low energy, and little to show for it in terms of results, even with strict dieting.

Another critical hormone for controlling weight and understanding our journey is called leptin. It’s a hormone that signals fullness and regulates metabolism. With repeating the same cycle of overeating and dieting, our brains can become leptin-resistant. When that happens, we’ll still receive hunger signals while the metabolism slows, making weight loss feel like an uphill battle. his is one reason why many people still feel hungry even when eating nutrient-dense foods.

Another important hormone when it comes to regulating weight is Cortisol, the stress hormone. Unsurprisingly, with the holidays having just wrapped up, cortisol levels tend to rise in January. Financial pressure from buying gifts and traveling, work demands and making up for those vacation days spent at Thanksgiving or the winter holidays, lack of sleep, and aggressive or even unrealistic fitness goals all contribute. Elevated cortisol levels will encourage fat storage, particularly around the belly and increases cravings for often unhealthy high-calorie foods. This is happening at the same time when someone may be starting or restarting workouts and under-eating when starting that new years diet plan which could push cortisol even higher, unintentionally working against fat loss.

Finally, the last hormone is ghrelin. Often thought of as the hunger hormone, ghrelin spikes with things like crash dieting and skipped meals when fasting. When ghrelin levels rise, hunger will start to increase, and a persons willpower will certainly be tested. Maintaining the necessary consistency for a weight loss journey becomes tough for many people. This is a type of built-in survival mechanism which takes serious will power to break and explains why so many people give up pretty quickly. This is why GLP-1 medications like tirzepatide and semaglutide (Mounjaro and Wegovy) are becoming so popular.

Sometimes what may help people reach their health and wellness goals is shifting the  focus from personal discipline and motivation to hormone support. TRT for men or HRT for women are options many people take to address the underlying symptoms when they are a result of sub-optimal endocrine functioning. Stabilizing blood sugar levels through healthy, well-balanced meals with adequate protein, fiber, and healthy fats could help reduce insulin spikes and curb cravings. Prioritizing things within our control like getting enough quality sleep, managing stress, and choosing sustainable exercise routines have been shown to lower cortisol and support metabolic health. Eating enough of the right foods rather than chronically undereating can help to restore leptin sensitivity and prevent long-term metabolic slowdown.

This hormone-centered perspective is central to the approach used at NovaGenix Health and Wellness. Instead of relying on willpower-based plans, their focus is on understanding how an individual’s body responds to stress, nutrition, and lifestyle. Under the guidance of Dr. Mackey, patients are encouraged to look beyond the scale and address the underlying hormonal patterns that influence weight, energy, and overall health.

By identifying and taking corrective steps to overcome these internal barriers, weight loss becomes easier, more effective, sustainable and far less exhausting. People who don’t see results within a few weeks often give up. January doesn’t need more motivation, what it needs is better alignment with how our bodies actually work. When our hormones are supported, hunger and appetite become manageable, energy typically improves, and progress will feel natural instead of forced and usually the results can be lasting instead of regaining weight right away. True success will come not from pushing harder, but from working with our bodies rather than against them.

Hidden Low T: Understanding the Symptom Triggers Your Lab Work Doesn’t Show

The Testosterone Level Tipping Point: Understanding Your Symptoms and Low T Thresholds

                    Beyond the Numbers: How to Know When Your Testosterone Is Truly Low

As men age, the conversation surrounding testosterone usually moves from general health to specific symptoms that each individual experiences. While a gradual, age-related decline of about 1-2% annually is typical for most of us, the point at which this natural change begins to have an impact a person’s quality of life is what truly matters. It happens slowly over time but one morning you wake up and start to realize that you aren’t the same man that you used to be. Getting up is harder. The motivation to hit the gym is gone or maybe you find that you’re gaining weight and have a decreased libido, just to name a few of the symptoms most men begin to experience. At NovaGenix Health and Wellness, we know that understanding your individual threshold is the first step toward reclaiming your vitality and improving the way that you feel so that the process of aging doesn’t have to mean decreased enjoyment in life.

The standard reference range for total testosterone in men will vary from one laboratory reference range or study to the next. Generally, it can be anywhere from 250 to 1,000  ng/dL which is broad and offers little insight into what constitutes a "healthy" level for you, or when that level starts causing noticeable symptoms. Age, genetics, lifestyle factors all contribute to what a normal testosterone level for a man is and since we’re all unique, it’s important to factor in the signs and symptoms of low T just as much as what the blood test results show…something many physicians won’t do. The real value lies in understanding the T-Level Tipping Points…the concentrations below which specific, debilitating symptoms become statistically more prevalent as this is where the levels actually matter as it begins to affect us in our lives and finding a doctor who prescribes testosterone is vital in this journey.

The Thresholds of Low T Symptoms

Research has provided us with a crucial insight into Low T and symptom onset by linking common symptoms of Low T (hypogonadism) to specific testosterone level thresholds. These findings have highlighted that many men will begin experiencing negative physical, sexual and mental/emotional changes long before their total T-level dips below the traditional "low" mark of 250 ng/dL.

Notice how some of the earliest and most common complaints of fatigue and weight gain will begin to appear when levels are still well within the supposedly "normal" range. For example, a man with a level of 380 ng/dL is technically within "normal" ranges but is already below the threshold where unwanted weight gain is observed to be more prevalent. Because the numbers are considered “normal” most doctors won’t even address this with the patient. This demonstrates why a simple lab value alone is often insufficient for proper diagnosis and treatment. Most general practitioners don’t even test hormone levels, let alone treat them. At our clinic we often get complaints about how their doctor won’t prescribe them testosterone and that they were told “It’s just a normal part of life.” We couldn’t disagree more. We believe that patients should be in control of their own medical decision making and we’re here to offer expert guidance and support along the way.

Beyond Total T: The Role of Bioavailable Testosterone in Men

To complicate matters even further for patients and providers, testosterone circulates in your blood in two primary forms: bound to proteins or in a "free," unbound state. With age, the binding protein SHBG (Sex Hormone-Binding Globulin) often increases, effectively "locking up" more testosterone. This means an older man might have a normal total testosterone reading but still possess lower levels of free or bioavailable testosterone, which is the only form your body can actively use for muscle building, energy, and mood regulation. This is why testing for both total and free/bioavailable testosterone is often recommended. We have seen patients with relatively high total T levels BUT with all the symptoms of suboptimal hormones. When the results for the free levels come back we have to look into WHY those levels are low and it turns out more often then not that SHBG is the culprit. Lowering Sex Hormone-Binding Globulin (SHBG) may be an option for optimizing hormone health because a high level reduces the amount of active, free testosterone available in the body however this may not always be an easy fix. Strategies to lower SHBG primarily involve improving insulin sensitivity through weight management and diet (reducing sugar/refined carbs, increasing healthy fats), and using over the counter supplements like Boron, Magnesium, and Vitamin D may help but often not enough to make a major impact on increasing bio-available testosterone levels.

Taking the Next Step for Better Health

If you or someone you know may be experiencing any combination of these symptoms—from a decrease in libido and/or erectile dysfunction to signs like persistently feeling drained, fatigue and mood swings—it's a good indication that your testosterone level is impacting your quality of life, regardless of where it falls on a generic reference chart. A test developed to determine whether you fall into the category, called the ADAM test (Androgen Deficiency in Aging Males) can help determine the probability of you having low T levels and can be taken online.

At NovaGenix, we emphasize a comprehensive approach that looks past a single number. Our physician, Dr. Timothy W. Mackey will evaluate your symptoms alongside your total and free testosterone levels (preferably tested in the morning for optimal accuracy), as well as other relevant health factors and biomarkers to determine your eligibility for hormone therapy. It’s a very simple and relatively non-invasive process.

Testosterone Replacement Therapy (TRT), is becoming more accepted and popular and can be available through injections, gels, patches, or pellets. It’s a highly effective treatment option for many men to restore androgen levels within normal levels and alleviate symptoms. Additionally, simple lifestyle modifications such as a eating a healthy diet, stress reduction techniques like yoga and getting adequate sleep each night, and targeted exercise like weight training can naturally support hormone production and improve overall health.

We tell our patients that you don't have to settle for "normal" if you don't feel normal. Consulting with an experienced healthcare provider who specializes in hormone replacement therapy is the first and most important step into understanding your unique overall hormonal picture and regaining your health and well-being as you age.

The Low T Options: Injections, Gels, Patches, and Pellets

Once you and your healthcare provider determine that Testosterone Replacement Therapy (TRT) is appropriate for you, the next decision to be made is choosing the right delivery method. The goal of TRT is to restore your T-levels to an optimal range, mitigating the symptoms of Low T like fatigue, low libido, and mood fluctuations.

Here is a breakdown of the most common TRT options, which are available through NovaGenix Health and Wellness:

1. Intramuscular Injections (Testosterone Cypionate/Enanthate)

• How it works: The testosterone is injected directly into a muscle (usually the glute or thigh).
• Frequency: Typically administered every one to two weeks.
• Pros: It is often the most cost-effective option and can provide higher total testosterone levels. The dosing schedule is simple and predictable.
• 
  Cons: Requires an injection, which some people dislike. It can lead to a "roller-coaster" effect, with high T-levels right after the shot and lower levels before the next dose.

2. Topical Gels and Solutions

• How it works: A clear gel is rubbed onto clean, dry skin (like the shoulders, upper arms, or abdomen) and absorbed into the bloodstream.
• Frequency: Applied daily, typically in the morning. (Here is a link for the best way to administer testosterone creams/gels)
• Pros: Provides steady, consistent testosterone levels, closely mimicking the body’s natural release. It is needle-free and easy to use.
• Cons: There is a risk of transference to partners or children if the application site is not covered. It may cause skin irritation in some users.

3. Patches (Transdermal Systems)

• How it works: A testosterone-containing patch is applied to a clean area of the skin.
• Frequency: Applied daily.
• Pros: Like gels, they offer a steady release of the hormone.
• Cons: They are sometimes visible and can cause significant skin irritation or a rash, which often leads to poor compliance.

4. Subcutaneous Pellets (Testosterone Implants)

• How it works: Small pellets, about the size of a grain of rice, are inserted under the skin (usually in the hip or buttocks area) during a minor office procedure.
• Frequency: The pellets dissolve slowly, requiring re-implantation every three to six months.
• Pros: This is a convenient option, eliminating the need for daily application or weekly injections. It provides a long-term solution to increase testosterone levels.
• Cons: Requires a minor surgical procedure for insertion and removal (if necessary), and the dose cannot be adjusted once inserted. Patients may notice a decrease in effectiveness of the pellet over time and cannot have their dose adjusted.  Also some patients get infections or the body pushes the pellets out though the skin.

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At the end of the day the best TRT protocol for you depends on your lifestyle, your comfort level with injections, and the consistency of your blood work. At NovaGenix, Dr. Mackey will work with you to find the treatment that  best optimizes your hormones while minimizing side effects. Call us today at 561-277-8260 to learn more and schedule a free initial consultation to discuss options with our expert medical team.

Here is a list of the studies and sources mentioned

• Study on Young Men's Testosterone Levels: The article cited a 2022 study titled, "What Is a Normal Testosterone Level for Young Men? Rethinking the 300 ng/dL Cutoff for Testosterone Deficiency in Men 20-44 Years Old," published in the Journal of Urology. (This study provided the data for men aged 20-44).
• General Reference Ranges: The article stated it used data from:
• Medical News Today in their article "Typical Testosterone Levels in Males and Females."
• Baptist Health in their article titled "Normal Testosterone Levels by Age."
• Alternative Reference Range: The University of Rochester Medical Center was mentioned as publishing a normal range between for men.
• Symptoms Thresholds: The article mentioned a cross-sectional cohort study involving 434 men that observed symptoms were more prevalent when testosterone levels fell below specific thresholds.
• Testosterone and Aging: Data on testosterone levels in healthy men aged 40 to 79 years was reported by Harvard Medical School in their article titled "Testosterone, Aging and the Mind."