Commercial or Compounded Testosterone? Choosing the Right TRT Option for You

Commercial Brand vs. Compounded Testosterone: Which Medication Should I Take for TRT?

Testosterone Therapy Simplified: Weighing Commercial Brands vs. Compounded Options

Testosterone Replacement Therapy (TRT) has become an increasingly popular medical treatment for men experiencing symptoms of low testosterone. Symptoms such as decreased libido, fatigue, and erectile dysfunction are just a few reasons why men decide to get tested, diagnosed and treated for what’s called male andropause or hypogonadism. While both commercial brand and compounded testosterone options exist, understanding their key differences is crucial for making informed decisions about treatment and can help patients decide which options are best for their individual needs.

Manufacturing and Quality Control

Commercial brand testosterone is produced by large pharmaceutical companies and adheres to strict FDA regulations. The manufacturing process involves large-scale production with automated machinery and rigorous testing to ensure consistency, purity, potency, and safety. These products are subject to stringent quality control measures, giving patients confidence in their reliability.

Here are some of the large pharmaceutical companies that manufacture testosterone:

• AbbVie: Manufactures AndroGel, a leading testosterone gel.
• Endo Pharmaceuticals: Produces several testosterone products, including Testim (gel), Fortesta (gel), and Testopel (pellets).
• Pfizer: Manufactures Depo-Testosterone, an injectable testosterone product.
• Allergan: Manufactures Androderm, a testosterone patch.
• Antares Pharma: Manufactures Xyosted, an injectable testosterone product.
• Clarus Therapeutics: Manufactures Jatenzo, an oral testosterone capsule.
• Aytu BioScience: Manufactures Natesto, a nasal testosterone gel.

 

In contrast, compounded testosterone is custom-made by licensed pharmacists in compounding pharmacies to meet individual patient needs. While these pharmacies follow specific regulatory standards, the level of oversight is not as rigorous as FDA-approved medications. They still have to get their medications tested and undergo multiple state inspections from state and other health department regulatory agencies that oversee pharmacy safety. This difference in regulation allows compounding pharmacies to provide greater customization for patients.

Types of Testosterone Formulations

Commercial brands typically offer a standardized range of formulations, including injectables (e.g., testosterone cypionate or enanthate), gels, and patches. Examples include AndroGel, Testim, Axiron, and Fortesta. These options are convenient but may not suit all patients' unique needs

Compounded testosterone provides more flexibility in formulation. Some patients may respond better to one form over the other, a different strength or even a specific ester such as cottonseed or grapeseed oil for example. A compounding pharmacy can produce a product that is patient specific which allows for more customized personal protocols for patients who are looking for the best testosterone to take for TRT.

Options include:

• Injectables: Customizable esters (e.g., cypionate, enanthate, or propionate) and oils (e.g., sesame or grapeseed oil) tailored to patient preferences and injection schedules. Offer excellent options in terms of flexibility and do not require invasive procedures like pellets or daily application like creams/gels.
• Topicals: Testosterone creams, gels, or lotions with varying concentrations and bases to address individual skin sensitivities. These are good options for those patients opposed to needles and injections.
• Pellets: Customizable in size and testosterone content for sustained release. Provide several months’ worth of hormone release without having to readminister a weekly injection or apply a daily topical cream.
• Other Forms: Unique options like oral tablets or nasal sprays, though these are less common.

This flexibility makes compounded testosterone ideal for patients with specific requirements or sensitivities as well as being often times, more cost effective.

Uses and Benefits

Both commercial and compounded testosterone aim to alleviate symptoms of low testosterone and improve quality of life. However, compounded testosterone offers additional benefits:

• Personalized Dosing: Allows precise adjustments based on individual responses and blood test results. One can maximize their dose in the most minimal volume as well as utilize the ester that agrees most with the patient’s specific genetic preference to the medication.
• Alternative Formulations: Addresses allergies or sensitivities to commercial product ingredients. Some patients may experience side effects from some formulas and a compounding pharmacy can make the necessary changes to alleviate the symptoms.
• Enhanced Compliance: Provides more convenient or comfortable options, such as customized cream bases or tailored injection schedules to ensure there are no lapses in dosing while following their doctors’ instructions and protocol.

Cost and Insurance Coverage

Cost is a significant factor when choosing between commercial and compounded testosterone. Commercial brands are often covered by insurance, although out-of-pocket costs can vary depending on the product, dosage, and insurance plan. Also, insurance companies may require a physician to prescribe a certain form and dose for reimbursement. In other words, the insurance company makes the patients protocol and if the doctor doesn’t follow it, they don’t get paid, and the patient would be responsible for the costs if they want to be treated. Patients looking to use insurance for TRT need to call their insurance provider to see what the specific requirements are for coverage. On the other hand, compounded testosterone is rarely covered by insurance, leading to out-of-pocket costs, but they do receive the protocol that will be best suited to their specific needs. Pricing for compounded medications depends on the formulation, quantity, and compounding pharmacy. Many clinics that specialize in hormone replacement therapy offer all inclusive HRT programs which make the treatment more affordable and convenient for patients seeking care from a qualified and experienced provider. Low T clinics offer several advantages in terms of convenience and expertise over other providers who may not have the specific background when it comes to this medical niche.

Considerations and Safety Concerns

While both options are effective, safety and quality are paramount:

• Commercial Brand: Backed by rigorous FDA oversight, ensuring consistent quality and safety.
• Compounded Testosterone: Requires careful selection of a reputable pharmacy to ensure adherence to high-quality standards.

Both options carry potential side effects, including acne, mood changes, increased red blood cell count, and cardiovascular risks. Regular monitoring by a healthcare provider is crucial to mitigate these risks.

Making the Right Choice

Choosing between commercial and compounded testosterone should be a collaborative decision between the patient and their healthcare provider. Factors to consider include:

• Individual Needs: Allergies, sensitivities, lifestyle, and preferred method of administration.
• Medical Necessity: Whether a compounded formulation is required to address unique health conditions.
• Cost and Insurance: Evaluating affordability and exploring insurance coverage options.
• Quality Assurance: Ensuring the compounding pharmacy has a strong reputation for safety and consistency.

Commercial brand testosterone offers reliability and FDA-approved safety, while compounded testosterone provides unmatched customization and flexibility. Each option has its benefits and potential drawbacks, and the decision should be guided by professional medical advice tailored to the patient’s individual needs. By working closely with a qualified healthcare provider, patients can make the best choice to achieve optimal health and well-being. To learn more about testosterone therapy and how you can get tested, diagnosed and treated, visit our website at www.NovaGenix.org or call/text us at 561-277-8260 today to schedule a free consultation.

 

Complete Guide to Administering Testosterone Injections: Methods, Tips, and Best Practic

Overview of Testosterone Injection Therapy

Testosterone injections are a key component of  Testosterone Replacement Therapy  (TRT), given either subcutaneously (beneath the skin) or intramuscularly (directly into the muscle). This guide provides step-by-step instructions for administering injections correctly and outlines the distinctions between these methods.

Types of Injectable Testosterone

There are various testosterone esters used in TRT, each differing in how the body absorbs them and the frequency of administration. Here are a few different types of injectable testosterone used in TRT:

• Testosterone Cypionate – A long-lasting ester, usually injected once per week.

• Testosterone Enanthate – Has a slightly shorter half-life than cypionate and is commonly injected one or two times weekly.

• Testosterone Propionate – A short-acting ester that requires injections every 2-3 days and may cause more irritation at the injection site.

Understanding Needles and Syringes

Needles

A needle is a slender, hollow instrument used to introduce medication into the body. It is classified by gauge (G), which indicates thickness, and length (in inches). A higher gauge number means a thinner needle. Commonly used sizes for testosterone administration include:

• Drawing needle: 18G–21G (1–1.5 inches) for efficiently extracting testosterone from the vial.

• Injection needle: 23G–27G (1–1.5 inches) to reduce discomfort during administration.

Syringes

Syringes have three key components:

• Barrel: Holds the fluid.

• Plunger: Controls the movement of the liquid.

• Tip: Connects to the needle.

Syringe sizes range from 0.3mL to 60mL. For testosterone doses under 1cc, a 1mL syringe provides precise measurement and easier control.

Insulin Syringes These range from 0.3mL to 1mL and are commonly recognized by their orange caps. Unlike standard syringes, their scale is measured in insulin units rather than milliliters. They are often used for medications like  hCG and GLP-1 weight loss drugs  treatments.

Steps for Safe Injection

Step 1: Assemble Required Supplies

Ensure you have the following:

• Your prescribed testosterone vial

• Alcohol wipes for cleaning

• A new syringe (1mL for smaller doses)

• A fresh drawing needle (18G-21G)

• A fresh injection needle (23G-27G)

• A Sharps container for proper disposal

Step 2: Clean and Prepare

• Wash your hands thoroughly for at least 20 seconds.

• Sanitize the rubber stopper of the vial with an alcohol wipe.

• Use new needles and syringes for every injection—never reuse them.   

Step 3: Drawing the Testosterone

• Secure the drawing needle onto the syringe.

• Pull the plunger to match the prescribed dose.

• Insert the needle into the vial and inject air to create pressure for easier extraction.

• Invert the vial and withdraw the appropriate dose.

• Remove the needle from the vial and draw in a small amount of air to clear residual testosterone.

Step 4: Switching to the Injection Needle

• Replace the drawing needle with a fresh injection needle.

• Ensure it is attached securely to prevent leaks.

Step 5: Remove Air Bubbles

• Lightly tap the syringe to release trapped air bubbles.

• Push the plunger until a small droplet appears at the needle tip.

Step 6: Performing the Injection

Sanitize the chosen injection site with an alcohol wipe. Choose the appropriate method:

Subcutaneous Injection (SubQ)

• Pinch a section of skin to create a fold.

• Insert the needle at a 45-degree angle if pinching one inch of skin, or at 90 degrees for two inches.

• Inject slowly and remove the needle at the same angle.

Intramuscular Injection (IM)

• For Intramuscular Sites for Injection, select a muscle such as the deltoid, thigh, or ventrogluteal area for. Click below for more detailed location

• Deltoid Muscle
• Vastus Lateralis
• Ventrogluteal Muscle 

• Stretch the skin tight and insert the needle at a 90-degree angle.

• Inject at a steady pace and withdraw the needle carefully.

Step 7: Safe Disposal

• Dispose of used needles and syringes in a Sharps container.

• If unavailable, use a sturdy, puncture-proof container with a secure lid and follow local disposal guidelines.

Choosing the Best Injection Site

Subcutaneous Injection Locations

• Upper Arm: Pinch the back of the arm midway down.

• Abdomen: Avoid injecting near the navel and instead use the waistline area.

• Thigh: Use the outer middle portion for accessibility.

• Gluteal Region: Inject in the upper quadrant of the buttock.

Intramuscular Injection Locations

• Deltoid Muscle: Inject two finger-widths below the shoulder bone.

• Vastus Lateralis (Thigh): Use the top outer part of the thigh for easier access.

• Ventrogluteal Muscle: This site, located on the side of the hip, is recommended as it avoids major nerves and blood vessels.

Finding the Ventrogluteal Injection Site

V Method:

• Use the opposite hand (left hand for the right hip, and vice versa).

• Place your thumb on the groin and your index finger on the iliac crest.

• Spread the middle finger to form a "V"; inject at the base of this V.

G Method:

• Visualize a triangle connecting key bone landmarks of the hip and thigh.

• Draw imaginary lines from the triangle’s corners.

• The intersection of these lines marks the injection site.

 

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Additional Resources and Support
For more detailed instructions on subcutaneous or intramuscular injections, or if you have any questions or concerns, please contact us at info@novagenix.org or call 561-277-8260.

Does Testosterone Help With Weight Loss?

Can Testosterone Help You Shed Pounds?

Testosterone and Weight Loss: Science-Backed Benefits of Optimized Hormones

Testosterone, the primary male sex hormone, plays a crucial role in various bodily functions, including muscle growth, bone density, and sex drive. But can this vital hormone also be a secret weapon in the battle of the bulge? Many of our patients come to us with several goals but one of the more common ones is to lose some weight. Will testosterone help? Yes.

The relationship between testosterone and weight loss is complex, but emerging evidence suggests that it may indeed play a significant role, particularly for men with low testosterone levels. This article will help you understand the science behind this connection, exploring how testosterone can impact weight management and offering insights for those considering testosterone therapy. There have been many studies looking at the connection between testosterone and weight loss and the evidence suggests the benefit of optimized hormones will have a positive impact on weight loss.

Understanding the Testosterone-Weight Connection

Testosterone exerts its influence on weight in several key ways:

• Increased Muscle Mass: Testosterone builds muscle. Testosterone is a potent anabolic hormone, stimulating protein synthesis and muscle growth. Muscle tissue is more metabolically active than fat tissue, meaning it burns more calories at rest. By increasing muscle mass, testosterone can boost your resting metabolic rate (RMR), helping you burn more calories throughout the day. Another benefit is that toned physique will make you feel better about yourself and can even motivate you to workout harder to increase those gains!
• Fat Redistribution: Testosterone can influence where fat is stored in the body. Low testosterone levels are often associated with increased visceral fat – the dangerous type of fat that accumulates around the organs. Testosterone therapy may help shift fat distribution, reducing visceral fat and promoting a healthier body composition and get rid of that “belly.” Testosterone can redefine what was once considered a typical ”Dad-Bod,”
• Improved Mood and Motivation: Low testosterone can contribute to fatigue, decreased motivation, and even depression. These factors can significantly hinder weight loss efforts. Who wants to work out when they’re down in the dumps? By improving mood and increasing energy levels, testosterone therapy can enhance your overall well-being and motivation to engage in regular exercise and maintain a healthy diet and make you much more pleasant to be around at both work and home.
• Enhanced Exercise Performance: Testosterone plays a crucial role in athletic performance. By increasing muscle strength and power, it can help you push harder during workouts, leading to greater calorie expenditure and improved fitness levels. But be careful as many sports organizations may ban supplemental testosterone, so before you start TRT, make sure you aren’t breaking any rules that govern any sport you may play.

Scientific Evidence: A Closer Look

While anecdotal evidence abounds and is often the first thing we see with our eyes and ultimately believe, scientific studies provide concrete support for the potential role of testosterone in weight management and prove that testosterone can help you lose weight and keep it off:

• Study 1: A study published in the Journal of Clinical Endocrinology & Metabolism investigated the effects of long-term testosterone therapy in men with testosterone deficiency. The study found that testosterone replacement therapy resulted in significant weight loss, reduced waist circumference, and improved body composition, including a decrease in body fat percentage.
• Key takeaway: This study provides strong evidence that testosterone therapy can be an effective tool for weight management in men with low testosterone levels.
• Study 2: Another study, published in the International Journal of Endocrinology, explored the impact of testosterone therapy on metabolic parameters in obese men with low testosterone. The researchers observed improvements in insulin sensitivity, blood sugar control, and lipid profiles, all of which are crucial for metabolic health and weight management.
• Key takeaway: This study highlights the potential of testosterone therapy to address underlying metabolic issues that contribute to weight gain and obesity.

Who Can Benefit from Testosterone Therapy for Weight Loss?

Testosterone therapy may be a viable option for weight management in specific cases. The first step is getting a blood test to actually measure your hormone levels and speak to your physician about your medical history, signs and symptoms and determine if your may qualify. Who may benefit from testosterone?

• Men with Low Testosterone: This is a logical enough answer. Individuals with confirmed low testosterone levels (hypogonadism), confirmed via and blood test and diagnosis, may experience significant weight loss and improved body composition with testosterone replacement therapy.
• Men with Obesity and Low Testosterone: Obesity itself can contribute to low testosterone levels. It causes a cycle that’s tough to break. Low T increases fat. Increased fat lowers testosterone. The cycle continues. In these cases, addressing both conditions simultaneously may yield the best results.

Important Considerations:

• Testosterone therapy is not a magic bullet for weight loss. It is most effective when combined with a healthy diet and regular exercise. Just taking testosterone will help, but it’s better to maximize results and make long lasting lifestyle changes.
• Testosterone therapy should only be considered under the supervision of a qualified healthcare professional. An experienced physician knowledgeable in this particular field of medicine will help yield the best results and potentially  reduce the chances of having any negative side effects.
• As just mentioned, TRT can cause potential side effects including acne, aggression, and an increased risk of prostate enlargement. All of these may be treated and the risks mitigated when under the care of a provider who knows what to look for and how to address them if they do start to occur.
• Individual results may vary. The effectiveness of testosterone therapy for weight loss can vary depending on individual factors such as age, lifestyle, and overall health. We’re all unique so what works for one may not work for all.

While not a standalone solution, testosterone therapy may offer a valuable adjunct to a comprehensive weight management plan for men with low testosterone levels and offer additional benefits for the patient to their overall health and quality of life. By addressing underlying hormonal imbalances, testosterone therapy can help improve muscle mass, boost metabolism, and enhance overall well-being, all of which can contribute to successful weight loss and improved quality of life however always speak to your doctor about the potential risks as well.

Disclaimer: This article is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before starting any new treatment or making significant changes to your diet or exercise routine.  

Testosterone Gels: Benefits, Risks, and Considerations for Men on TRT

Testosterone Gels: A Convenient Option for Testosterone Replacement Therapy

Testosterone, the primary male sex hormone, plays a vital role in various bodily functions, including muscle growth, bone health, red blood cell production, sexual function, and mood. However, testosterone levels naturally decline with age, and some men may experience low testosterone (hypogonadism) due to various factors.

Testosterone Replacement Therapy (TRT) is a medical treatment that aims to restore healthy testosterone levels. One popular delivery method for TRT is testosterone gels. These gels are applied directly to the skin, allowing for convenient and discreet administration.

Benefits of Testosterone Gels:

• Convenience: Easy to apply at home.
• Flexibility: Dosage and application schedules can be easily adjusted.
• Minimal systemic side effects: Generally have fewer systemic side effects compared to injections.

Common Testosterone Gel Brands:

• AndroGel: Available in 1% and 1.62% strengths. Applied to the shoulders and upper arms.

• Testim: 1% strength gel applied to the shoulders and upper arms.

• Fortesta: 1% strength gel applied to the shoulders and upper arms.

• Vogelxo: 1% strength gel available in tubes, packets, and a pump. Applied to the shoulders and upper arms.

Important Considerations:

• Skin irritation: Possible side effect at the application site.
• Accidental transfer: Can transfer to others through skin-to-skin contact.
• Pregnancy risks: Pregnant women should avoid contact with the gel and treated skin.
• Monitoring: Regular blood tests are necessary to monitor testosterone levels and adjust dosage as needed.

Consulting a Healthcare Professional:

It's crucial to consult with a qualified healthcare professional before starting TRT with testosterone gels. They can:

• Diagnose low testosterone.
• Determine the appropriate dosage.
• Monitor your progress and adjust treatment as needed.
• Discuss potential risks and side effects.

Disclaimer: This information is for general knowledge and informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional ¹ for any health concerns or before making any decisions regarding your health or treatment.  

 Testosterone Replacement Therapy.  

testosterone levels in men  

What are normal testosterone levels for a man?

Testosterone fuels the development of lean muscle 

 Testosterone gels 

The appropriate dosage and strength of testosterone 

unwanted side effects 

blood tests to confirm a testosterone deficiency. 

This information is not exhaustive, and new products may be available. It's essential to consult with a healthcare provider or pharmacist for the most up-to-date information on available testosterone products and their appropriate use.
 

Disclaimer:
This blog post is for informational purposes only and should not be considered medical advice. Always consult with a healthcare professional for any health concerns or before starting any new treatment.