Commercial vs. Compounded Testosterone: How to Choose the Right TRT Option

Deciding on Testosterone Replacement: Commercial vs. Customized Options

Testosterone Replacement Therapy  (TRT) has become a common remedy for men facing symptoms of low testosterone, ( male andropause ) such as reduced libido, persistent fatigue, and erectile challenges. Men dealing with male andropause or hypogonadism are increasingly seeking diagnosis and treatment. When exploring TRT, it’s important to understand the differences between commercially manufactured products and customized (compounded) formulations to determine which approach best meets individual needs.

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Production and Regulatory Oversight

Commercial Testosterone:
Major pharmaceutical companies produce commercial testosterone under strict FDA guidelines. These products are manufactured on a large scale using automated processes that include extensive testing to ensure consistent potency, purity, and safety. This rigorous quality control reassures patients about the reliability of these medications. For example:

• AbbVie produces AndroGel, a well-known testosterone gel.
• Endo Pharmaceuticals offers products such as Testim, Fortesta, and Testopel.
• Pfizer manufactures Depo-Testosterone, an injectable form.
• Allergan makes Androderm, a transdermal patch.
• Antares Pharma, Clarus Therapeutics, and Aytu BioScience also contribute to the market with products like Xyosted, Jatenzo, and Natesto respectively.

Customized (Compounded) Testosterone:
In contrast, compounded testosterone is tailored to the patient by licensed pharmacists in specialized compounding pharmacies. Although these pharmacies adhere to specific regulatory standards and undergo periodic inspections by state agencies, the oversight is less stringent compared to FDA-approved products. This approach, however, allows for greater personalization to match the unique requirements of each patient while being under the influence of  health department regulatory agencies ensuring safety.

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Formulation Flexibility

Standardized Options:
Commercial brands typically offer a set range of formulations, including injectables (like testosterone cypionate or enanthate), gels, and patches. These options—such as AndroGel, Testim, Axiron, and Fortesta—are convenient for many, though they may not suit every individual’s needs they provide flexibility to help a patient decide what the best testosterone to take for TRT for them is.

Personalized Formulations:
Compounded testosterone provides enhanced flexibility, allowing for adjustments in dosage strength, the type of ester used, and even the base oil (for instance, sesame or grapeseed oil). This customization can be especially beneficial for patients with specific sensitivities or preferences. Options include:

• Injectable Solutions: Customizable esters and oils that align with the patient’s schedule and comfort.
• Topical Applications: Testosterone creams, gels or lotions formulated in various concentrations to accommodate skin sensitivities.
• Pellet Implants: Tailored pellets designed for sustained hormone release over several months.
• Other Forms: Less common options like oral tablets or nasal sprays.

This versatility often makes compounded testosterone a more attractive choice for those who require a personalized approach.

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Benefits and Considerations

Both commercial and compounded testosterone aim to alleviate the symptoms associated with low testosterone and improve overall quality of life. However, compounded formulations offer specific advantages:

• Customized Dosing: Allows for precise adjustments based on individual responses and lab results.
• Alternative Ingredients: Provides options for patients who might be allergic or sensitive to certain ingredients found in commercial products.
• Enhanced Convenience: Tailored administration schedules and formulations can improve treatment adherence.

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Cost and Insurance Implications

Financial considerations play a critical role in selecting a TRT option.

• Commercial Products: Often covered by insurance, though coverage details may vary by product, dosage, and the specific requirements set by the insurance provider.
• Compounded Medications: Generally not covered by insurance, meaning patients may face higher out-of-pocket expenses. However, many specialized hormone replacement clinics offer all-inclusive programs that can help manage costs while providing expert care.

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Safety and Monitoring

Both treatment options require careful monitoring.

• Commercial Medications: Benefit from rigorous  FDA oversight, ensuring a high standard of quality and safety.
• Customized Formulations: Depend on the reputation and reliability of the compounding pharmacy; selecting a trusted provider is crucial.
• Potential Side Effects: Both options can have side effects such as acne, mood fluctuations, increased red blood cell counts, and cardiovascular risks, making regular check-ups with a healthcare provider essential to avoid or mitigate the potential for Allergies, sensitivities or other unwanted condition.

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Making the Right Choice

Deciding between commercial and compounded testosterone should be a collaborative process involving the patient and their healthcare provider. Key factors to consider include:

• Personal Needs: Consider allergies, lifestyle, and preferred administration methods.
• Medical Requirements: Determine if a personalized formulation is necessary to address specific health concerns.
• Cost and Insurance: Evaluate affordability and understand the details of insurance coverage.
• Quality Assurance: Ensure any compounding pharmacy chosen has a strong track record for quality and safety.

Commercial testosterone offers reliability and standardization, while compounded options provide the flexibility to fine-tune treatment. With professional guidance, patients can choose the option that best supports their health and well-being.

For further information on testosterone therapy, testing, diagnosis, and treatment options, visit www.NovaGenix.org or call/text 561-277-8260 to schedule a free consultation.

Testosterone Therapy Simplified: Weighing Commercial Brands vs. Compounded Options

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Complete Guide to Administering Testosterone Injections: Methods, Tips, and Best Practic

Overview of Testosterone Injection Therapy

Testosterone injections are a key component of  Testosterone Replacement Therapy  (TRT), given either subcutaneously (beneath the skin) or intramuscularly (directly into the muscle). This guide provides step-by-step instructions for administering injections correctly and outlines the distinctions between these methods.

Types of Injectable Testosterone

There are various testosterone esters used in TRT, each differing in how the body absorbs them and the frequency of administration. Here are a few different types of injectable testosterone used in TRT:

• Testosterone Cypionate – A long-lasting ester, usually injected once per week.

• Testosterone Enanthate – Has a slightly shorter half-life than cypionate and is commonly injected one or two times weekly.

• Testosterone Propionate – A short-acting ester that requires injections every 2-3 days and may cause more irritation at the injection site.

Understanding Needles and Syringes

Needles

A needle is a slender, hollow instrument used to introduce medication into the body. It is classified by gauge (G), which indicates thickness, and length (in inches). A higher gauge number means a thinner needle. Commonly used sizes for testosterone administration include:

• Drawing needle: 18G–21G (1–1.5 inches) for efficiently extracting testosterone from the vial.

• Injection needle: 23G–27G (1–1.5 inches) to reduce discomfort during administration.

Syringes

Syringes have three key components:

• Barrel: Holds the fluid.

• Plunger: Controls the movement of the liquid.

• Tip: Connects to the needle.

Syringe sizes range from 0.3mL to 60mL. For testosterone doses under 1cc, a 1mL syringe provides precise measurement and easier control.

Insulin Syringes These range from 0.3mL to 1mL and are commonly recognized by their orange caps. Unlike standard syringes, their scale is measured in insulin units rather than milliliters. They are often used for medications like  hCG and GLP-1 weight loss drugs  treatments.

Steps for Safe Injection

Step 1: Assemble Required Supplies

Ensure you have the following:

• Your prescribed testosterone vial

• Alcohol wipes for cleaning

• A new syringe (1mL for smaller doses)

• A fresh drawing needle (18G-21G)

• A fresh injection needle (23G-27G)

• A Sharps container for proper disposal

Step 2: Clean and Prepare

• Wash your hands thoroughly for at least 20 seconds.

• Sanitize the rubber stopper of the vial with an alcohol wipe.

• Use new needles and syringes for every injection—never reuse them.   

Step 3: Drawing the Testosterone

• Secure the drawing needle onto the syringe.

• Pull the plunger to match the prescribed dose.

• Insert the needle into the vial and inject air to create pressure for easier extraction.

• Invert the vial and withdraw the appropriate dose.

• Remove the needle from the vial and draw in a small amount of air to clear residual testosterone.

Step 4: Switching to the Injection Needle

• Replace the drawing needle with a fresh injection needle.

• Ensure it is attached securely to prevent leaks.

Step 5: Remove Air Bubbles

• Lightly tap the syringe to release trapped air bubbles.

• Push the plunger until a small droplet appears at the needle tip.

Step 6: Performing the Injection

Sanitize the chosen injection site with an alcohol wipe. Choose the appropriate method:

Subcutaneous Injection (SubQ)

• Pinch a section of skin to create a fold.

• Insert the needle at a 45-degree angle if pinching one inch of skin, or at 90 degrees for two inches.

• Inject slowly and remove the needle at the same angle.

Intramuscular Injection (IM)

• For Intramuscular Sites for Injection, select a muscle such as the deltoid, thigh, or ventrogluteal area for. Click below for more detailed location

• Deltoid Muscle
• Vastus Lateralis
• Ventrogluteal Muscle 

• Stretch the skin tight and insert the needle at a 90-degree angle.

• Inject at a steady pace and withdraw the needle carefully.

Step 7: Safe Disposal

• Dispose of used needles and syringes in a Sharps container.

• If unavailable, use a sturdy, puncture-proof container with a secure lid and follow local disposal guidelines.

Choosing the Best Injection Site

Subcutaneous Injection Locations

• Upper Arm: Pinch the back of the arm midway down.

• Abdomen: Avoid injecting near the navel and instead use the waistline area.

• Thigh: Use the outer middle portion for accessibility.

• Gluteal Region: Inject in the upper quadrant of the buttock.

Intramuscular Injection Locations

• Deltoid Muscle: Inject two finger-widths below the shoulder bone.

• Vastus Lateralis (Thigh): Use the top outer part of the thigh for easier access.

• Ventrogluteal Muscle: This site, located on the side of the hip, is recommended as it avoids major nerves and blood vessels.

Finding the Ventrogluteal Injection Site

V Method:

• Use the opposite hand (left hand for the right hip, and vice versa).

• Place your thumb on the groin and your index finger on the iliac crest.

• Spread the middle finger to form a "V"; inject at the base of this V.

G Method:

• Visualize a triangle connecting key bone landmarks of the hip and thigh.

• Draw imaginary lines from the triangle’s corners.

• The intersection of these lines marks the injection site.

 

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Additional Resources and Support
For more detailed instructions on subcutaneous or intramuscular injections, or if you have any questions or concerns, please contact us at info@novagenix.org or call 561-277-8260.

How Does Testosterone Help Men With Weight Loss?

Can Testosterone Help You Shed Unwanted Pounds? Science Says Yes!

Testosterone and Weight Management: How Optimized Hormones Can Boost Your Weight Loss Journey

 testosterone and weight loss 

Can TRT Help Shed Pounds Testosterone—known for its vital role in muscle growth, bone density, and libido—may also aid in weight loss, particularly for men with low testosterone (Low T). Optimized Testosterone builds muscle, boosts metabolism, and reduces fat—especially the harmful visceral type. Studies support testosterone therapy's role in improving body composition and metabolic health, however, results are most effective when combined with healthy lifestyle changes. Curious about how testosterone can help you lose weight? 

Testosterone, the primary male hormone, is essential for muscle growth, bone strength, and maintaining libido. But can it also serve as an ally in shedding extra pounds? Many patients ask whether enhancing testosterone levels can aid in weight loss—and the answer is yes.

Emerging research and many studies conducted on the topic suggest that optimizing testosterone can significantly impact weight management, especially in men with low hormone levels. This article explores the scientific basis behind this connection and explains how balanced testosterone may improve fat loss and overall body composition.

How Testosterone Influences Weight

• Muscle Growth:
  Testosterone is a powerful anabolic hormone that promotes protein synthesis and muscle development. Since muscle tissue burns more calories than fat even at rest, increasing muscle mass can elevate your resting metabolic rate. A more toned physique can also boost confidence and further motivate exercise.

• Fat Distribution:
  Low testosterone is often linked to increased visceral fat—the type stored around vital organs. Testosterone therapy may help shift fat distribution, reducing harmful visceral fat and contributing to a healthier body shape.

• Mood and Energy:
  A drop in testosterone can lead to fatigue, low motivation, and even depressive symptoms, all of which hinder weight loss efforts. By enhancing energy levels and overall mood, testosterone therapy can make it easier to stick to regular workouts and a balanced diet.

• Exercise Performance:
  Higher testosterone levels can improve strength and endurance, allowing for more effective workouts that burn additional calories. However, athletes should note that some sports organizations restrict supplemental testosterone use.

Scientific Evidence Supporting Testosterone’s Role

Multiple studies underscore testosterone’s potential in weight management. One study in the Journal of Clinical Endocrinology & Metabolism found that long-term testosterone therapy in men with deficiency led to notable weight loss, a reduced waistline, and better body composition. Testosterone can influence where fat is stored in the body Similarly, research published in the International Journal of Endocrinology reported improvements in insulin sensitivity, blood sugar regulation, and lipid profiles—factors essential for combating obesity.

Who May Benefit?

Testosterone therapy may be especially beneficial for:

• Men with Low Testosterone:
  Individuals with confirmed hypogonadism often experience significant weight loss and improved body composition with appropriate testosterone treatment.
• Overweight Men with Low Hormone Levels:
  Obesity can contribute to lower testosterone, creating a cycle where increased fat further suppresses hormone levels. Addressing both issues together may yield the most effective results.

Food For Though: An Intelligent Approach to Optimize Hormones, Raise Testosterone and Lose Weight

While testosterone therapy can assist with weight loss, it is not a miracle cure. Its benefits are best realized when paired with a nutritious diet and regular exercise. Moreover, testosterone treatments should only be undertaken with guidance from a qualified healthcare provider due to potential side effects such as acne, mood fluctuations, and an increased risk of prostate enlargement. Individual responses to therapy vary, so personalized medical advice is crucial.

Testosterone therapy, while not a standalone solution, can be an important part of a comprehensive weight management strategy for men with low testosterone. By addressing hormonal imbalances, it may boost muscle mass, accelerate metabolism, and improve overall well-being, all contributing to sustainable weight loss. Always consult your healthcare professional to understand the risks and benefits before starting any new treatment.

Disclaimer: This article is for informational purposes only and should not be considered medical advice. Please consult a healthcare professional before making any changes to your treatment plan or lifestyle.

•  Journal of Clinical Endocrinology & Metabolism  
• International Journal of Endocrinology

Testosterone Gels: Benefits, Risks, and Considerations for Men on TRT

Testosterone Gels: A Convenient Option for Testosterone Replacement Therapy

Testosterone, the primary male sex hormone, plays a vital role in various bodily functions, including muscle growth, bone health, red blood cell production, sexual function, and mood. However, testosterone levels naturally decline with age, and some men may experience low testosterone (hypogonadism) due to various factors.

Testosterone Replacement Therapy (TRT) is a medical treatment that aims to restore healthy testosterone levels. One popular delivery method for TRT is testosterone gels. These gels are applied directly to the skin, allowing for convenient and discreet administration.

Benefits of Testosterone Gels:

• Convenience: Easy to apply at home.
• Flexibility: Dosage and application schedules can be easily adjusted.
• Minimal systemic side effects: Generally have fewer systemic side effects compared to injections.

Common Testosterone Gel Brands:

• AndroGel: Available in 1% and 1.62% strengths. Applied to the shoulders and upper arms.

• Testim: 1% strength gel applied to the shoulders and upper arms.

• Fortesta: 1% strength gel applied to the shoulders and upper arms.

• Vogelxo: 1% strength gel available in tubes, packets, and a pump. Applied to the shoulders and upper arms.

Important Considerations:

• Skin irritation: Possible side effect at the application site.
• Accidental transfer: Can transfer to others through skin-to-skin contact.
• Pregnancy risks: Pregnant women should avoid contact with the gel and treated skin.
• Monitoring: Regular blood tests are necessary to monitor testosterone levels and adjust dosage as needed.

Consulting a Healthcare Professional:

It's crucial to consult with a qualified healthcare professional before starting TRT with testosterone gels. They can:

• Diagnose low testosterone.
• Determine the appropriate dosage.
• Monitor your progress and adjust treatment as needed.
• Discuss potential risks and side effects.

Disclaimer: This information is for general knowledge and informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional ¹ for any health concerns or before making any decisions regarding your health or treatment.  

 Testosterone Replacement Therapy.  

testosterone levels in men  

What are normal testosterone levels for a man?

Testosterone fuels the development of lean muscle 

 Testosterone gels 

The appropriate dosage and strength of testosterone 

unwanted side effects 

blood tests to confirm a testosterone deficiency. 

This information is not exhaustive, and new products may be available. It's essential to consult with a healthcare provider or pharmacist for the most up-to-date information on available testosterone products and their appropriate use.
 

Disclaimer:
This blog post is for informational purposes only and should not be considered medical advice. Always consult with a healthcare professional for any health concerns or before starting any new treatment.