Tesamorelin: Your Guide to Growth Hormone Peptide Therapy Benefits

Tesamorelin: Growth Hormone Releasing Peptide Therapy

What is the Peptide Tesamorelin?

Tesamorelin, an FDA-approved synthetic peptide, acts as a growth hormone-releasing hormone (GHRH), stimulating the pituitary gland to release growth hormone. This triggers the breakdown of lipids and triglycerides, primarily targeting excess fat in the abdomen. It is commonly prescribed to adults with HIV-related lipodystrophy to alleviate abdominal fat accumulation

 

Tesamorelin is particularly effective in targeting visceral fat around the abdomen, leading to a substantial reduction in abdominal weight, typically ranging from fifteen to seventeen percent (15-20%) over a twenty-six-week period. Moreover, recent studies conducted in 2014 have demonstrated its ability to decrease fat accumulation around the liver by as much as eighteen percent (18%). Notably, Tesamorelin has shown promising results in reducing visceral fat buildup in individuals experiencing lipodystrophy linked to HIV infection and antiretroviral therapy

Lipodystrophy encompasses a range of abnormal or degenerative conditions affecting the body's fat tissue. This condition may present as abnormal fat distribution (lipohypertrophy), fat tissue loss (lipoatrophy), or a combination of both. Lipodystrophy can either be inherited (congenital) or acquired, often arising as a consequence of certain medical interventions such as antiretroviral therapy for HIV/AIDS.

In the context of HIV/AIDS treatment, lipodystrophy frequently accompanies metabolic complications, including insulin resistance, dyslipidemia (abnormal blood lipid levels), and other cardiovascular risk factors. It can impact various body regions such as the face, arms, legs, and abdomen, altering body shape and appearance. Tesamorelin presents a viable option for individuals aiming to target stubborn areas like the abdomen, distinguishing itself from conventional weight loss programs.

 

How Does Tesamorelin Work?

Tesamorelin works by stimulating the receptors for GHRH, (growth hormone-releasing hormone) in the brain at the pituitary gland, thus initiating the synthesis and secretion of gh. This hormone will subsequently act on different cells all through the body, including cells such as hepatocytes located in the liver, where it causes the production of (IGF-1) insulin-like growth factor-1, which is why we advise the careful monitoring of IGF-1 levels for any elevation of the hormone during tesamorelin treatment.

IGF-1 serves as a pivotal mediator for numerous growth hormone effects, facilitating growth promotion, cell death prevention, glucose uptake enhancement, and initiation of lipolysis—the breakdown of fats. Individuals with conditions like obesity, diabetes, and lipodystrophy frequently exhibit low levels of serum IGF-1.

 

Tesamorein is alot like Ipamorelin and Sermorelin in how it works however it has been shown to be better at activating growth hormone production in the body. Also, ipamorelin had been added to the FDA category 2 bulk drug substances in September of 2023, which means that the pharmacies who were manufacturing and dispensing it are no longer compounding it, thus making it quite difficult to obtain, which makes Sermorelin and Tesamorelin the go to choice for patients.

 

 

How Is Tesamorelin Taken?

Tesamorelin is taken subcutaneously by injection using a small insulin needle and has significant effects on both glucose and lipid metabolism. Better knownunder it's brand name, Egrifta, The product is available in 1 mg/mL vials, presenting Tesamorelin in a solution format. Usually, the recommended dosage is 2 mg per day, administered through subcutaneous injection. Adverse effects, though infrequent, might encompass reactions at the injection site, itching, joint and muscle discomfort, and peripheral swelling.

Molecular Structure of Tesamorelin

Tesamorelin consists of 44 amino acids of GHRH, combined with a trans-3-hexenoic acid group. This polypeptide has its N-terminal segment modified to improve stability and pharmacokinetic properties compared to natural GHRH.

The inclusion of the trans-3-hexenoic acid group enhances Tesamorelin's effectiveness. GHRH, typically synthesized in the hypothalamus, plays a vital role in regulating hormone secretion and other physiological functions. Upon release, GHRH stimulates the pituitary gland to secrete growth hormones into the bloodstream, maintaining physiological balance. As a crucial component of Tesamorelin, these amino acids facilitate its function as a synthetic growth hormone-releasing hormone (GHRH).

Pharmacology: Mechanism of Action

Tesamorelin binds to receptors for pituitary growth hormone-releasing factor (GRF), initiating the secretion of natural growth hormone with anabolic and lipolytic properties. Growth hormone affects various cells such as osteoblasts, myocytes, hepatocytes, and adipocytes, leading to a reduction in total fat mass. These effects are primarily driven by the production of IGF-1 in both the liver and peripheral tissues.

Benefits of Tesamorelin

• Noticeable increase of IGF-1 (Growth Hormone)
• Targeting of visceral fat especially around the abdomen
• Helps build lean muscle mass and increases definition
• Benefits overall heart health
• Speeds up recovery after workouts

Who Is a Good Candidate?

Tesamorelin emerges as an excellent peptide for individuals seeking to regulate body composition, sculpt their physique, reduce abdominal fat, fortify their immune system, and elevate their overall well-being, helping them achieve their optimal look and feel. Both men and women grappling with stubborn belly fat or love handles can experience significant benefits from this treatment.

Before Taking Tesamorelin

Its vital to consult your doctor, especially if they are experienced in prescribing peptides. This is especially true for patients with pre-existing conditions such as pituitary gland disorders or allergies. Anti-Aging doctors  are good examples of healthcare provides to speak with. If the are experienced with peptide therapy they will be more familiar with this branch of medication and treatment and provide better tailer solutions for treatment options.

How to Take Tesamorelin

Usually, it's injected subcutaneously into the abdominal skin once daily using a 30g insulin needle, following the mixing of the lyophilized powder with sterile bacteriostatic water. The dosage and frequency depend on individual considerations and are typically determined after consulting a physician. Generally, it's taken 5-7 times weekly at bedtime since nighttime is when most IGF-1 production happens

Side Effects of Tesamorelin

Like with any medication, Tesamorelin may lead to certain adverse effects, usually not requiring immediate medical attention. Typically, these effects diminish as your body becomes accustomed to the medication. However, if you experience any side effects, it's important to contact your healthcare provider promptly for guidance. In case of a medical emergency, dial 911. Your healthcare provider can offer advice, suggestions, or strategies to alleviate potential side effects. Common side effects of Tesamorelin might include depression, muscle pain, or swelling at the injection site. Severe side effects such as rash or rapid heartbeat are rare.

Results and Consultation
Results for patients will vary depending on differences amongst individuals, but  fat loss may be observed after a few weeks of peptide therapy. Visit us at NovaGenix Health and Wellness for a free initial consultation to discuss your personalized peptide therapy treatment options. To learn more, check us out online at www.NovaGenix.org or give us a call us at 561-277-8260. We offer telemedicine consults and our US based, licensed and accredited pharmacies can deliver the medication directly to your door!