The Truth About Long-Term Testosterone Therapy: Benefits, Risks, and What to Expect
Is TRT Safe for Long-Term Use?
Testosterone
Replacement Therapy (TRT) is an increasingly popular medical treatment
among men experiencing symptoms associated with low testosterone, including reduced
muscle mass, low
libido, poor sleep quality, unwanted weight gain and mood changes. While
TRT has shown promising results in addressing these symptoms, many wonder about
the safety of TRT over the long term. At NovaGenix Health and Wellness, we
prioritize educating our patients about both the benefits and potential risks
of any treatment. As it turns out there is a significant body of research which
highlights the health benefits and safety of TRT. Here, we’ll explore the
considerations around long-term TRT safety, based on the latest research and
clinical insights from unbiased clinical researchers through evidence based
trials and peer reviewed literature.
Understanding How TRT Works
TRT aims to restore testosterone
levels to a healthy range. Testosterone,
a hormone produced in the testicles, plays a key role in male health,
impacting muscle mass, bone density, energy, and sexual function. Low
testosterone (or "low T") can result from age-related decline,
certain medical conditions, or lifestyle factors. TRT provides a way to supplement
testosterone levels through various methods, such as injections, gels, patches,
or pellets, each with its own benefits depending on a patient's lifestyle and
health needs. After a consultation with a licensed and experienced physician,
the protocol
and dose of testosterone may be determined based on the patient’s blood
work and signs/symptoms. The dose and frequency will vary from patient to the
next and after a few weeks, follow up blood work will be conducted to determine
the efficacy of treatment and if any adjustments need to be made.
Immediate Benefits of TRT
For many, TRT provides substantial health and quality of
life benefits shortly after starting treatment. Patients often report improved
energy levels, a clearer focus, increased libido, and better mood regulation
within weeks to months. Some men also notice improved muscle tone, decreased
body fat, and a general sense of well-being. For those struggling with the
symptoms of low T, TRT can be transformative. Every patient is different and the
time frame and results will be unique, which is why its best to work with
healthcare professionals that are experienced in hormone therapy to maximize the
potential benefits of treatment.
Links to Scholarly Articles and Clinical Research Trials
2.On
the effects of testosterone on brain behavioral functions
3.Testosterone
and Its Effects on Human Male Adolescent Mood and Behavior: A Systematic Review
4.Effects
of testosterone and growth hormone on muscle function
5.Testosterone
and weight loss: the evidence
Common Concerns with Long-Term TRT
The question of long-term safety with TRT is understandable,
as it involves a continuous adjustment to one’s hormonal balance. Historically
there has been much confusion and misinformation regarding the safety of
testosterone therapy however, it’s been studied and shown to be not only safe
when done under the guidance of a medical professional but can also improve
overall health and quality of life in patients with optimized hormone levels. An
This is clearly outilend ina n article title
“Efficacy and
Safety of Testosterone Treatment in Men: An Evidence Report for a Clinical
Practice Guideline by the American College of Physicians.” It states that In
older men with low testosterone levels without well-established medical
conditions known to cause hypogonadism, testosterone therapy may provide improvements
in sexual functioning and quality of life. In another article titled “Testosterone Replacement
Therapy: Long-Term Safety and Efficacy” it was concluded that “Among men
with androgen deficiency, those who were dispensed T prescriptions were
associated with a lower risk of CV outcomes “
Here are the most common concerns associated with prolonged
TRT use and what the latest research tells us:
Cardiovascular Health: Testosterone has been linked
to heart health in complex ways. Some early studies raised concerns about an
increased risk of cardiovascular events like heart attacks and strokes in men
on TRT. However, it was concluded that many of the male subjects in the studies
that came to this conclusion were older men with preexisting heart conditions.
More recent studies suggest that men with testosterone levels in the normal
range have a lower risk of cardiovascular issues compared to those with low
levels. A study in the Journal
of the American Heart Association even found that men on TRT had fewer
heart issues when testosterone levels were optimized, particularly when
monitored by a healthcare provider.
Prostate Health: Testosterone has long been thought
to influence prostate health, and there were concerns that TRT
could increase the risk of prostate cancer or benign prostatic hyperplasia (BPH).
While high testosterone levels may stimulate prostate cell growth, no strong
evidence links TRT to an increased prostate cancer risk. In fact, a 2016 study
in European Urology found no significant difference in prostate cancer
rates between men on TRT and those who were not. Regular screenings and PSA
testing are essential, as they allow healthcare providers to monitor prostate
health carefully. Its even been concluded that TRT can help patients that have
had prostate cancer post treatment. In a statement made from the American
Urological Association, it states…“Several studies have suggested that TTh
may decrease the risk of developing aggressive prostate cancer or developing a
biochemical recurrence after radical prostatectomy.” [Testosterone
Therapy for Patients with a History of Prostate Cancer By: Mohit Khera, MD,
MBA, MPH | Posted on: 01 Apr 2022]
Fertility Considerations: Long-term TRT can impact
fertility by reducing sperm production. This happens because external
testosterone creams/gels and injections can signal the hypothalamus to trigger
the body to stop producing its own testosterone, thereby affecting the
production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH),
both crucial for sperm production. Men who wish to preserve fertility may
explore alternative options or adjunct therapies, such as human chorionic gonadotropin (hCG),
to maintain sperm production while on TRT. Discussing fertility goals with a
healthcare provider before starting TRT is important for any man considering
long-term use.
Red Blood Cell Count (Polycythemia): TRT can
stimulate the production of red blood cells, potentially leading to a condition
called polycythemia, where the blood becomes thicker. Elevated red blood cell
counts can increase the risk of blood clots, stroke, and other cardiovascular
issues. Regular blood tests allow healthcare providers to monitor red blood
cell counts and hematocrit
levels for patients on TRT and adjust dosages or recommend phlebotomy
(blood donation) if levels get too high or other strategies aimed at lowering
red blood cell counts.
Mood and Mental Health: Testosterone is
closely tied to mental well-being whether levels are either too high or too
low. Many men report improved mood and reduced anxiety when on TRT, and some
studies even show a correlation between low testosterone and mood disorders.
While the short-term mood benefits are generally positive, it’s crucial to
monitor any long-term mood changes when taking hormones. In some cases, too
high or unstable testosterone levels may contribute to irritability or mood
swings and T levels
that are too low may contribute to depression. An article published by the
National Library of Medicine stated “…testosterone administration yielded
positive results in the treatment of depression.” It should be stated that not all cases may
benefit from the administration of testosterone, but the fact that the link
exists speaks volumes about the relationship between mental health and hormone balance
in men.
Importance of Medical Monitoring
One of the keys to the safe, long-term use of TRT is
consistent medical oversight from a licensed and experienced physician like Dr. Timothy W. Mackey from
NovaGenix. At NovaGenix Health and Wellness, we recommend regular check-ins
with our healthcare providers to monitor testosterone levels and overall health
indicators such as the signs and symptoms of Low T. Routine blood tests allow
for monitoring of things like red blood cell count, PSA levels, and hormone
levels, ensuring that any adjustments to the therapy can be made proactively.
Adjusting the TRT dose as needed helps minimize risks and promotes sustainable,
long-term benefits and improves overall medical outcomes from therapy.
Lifestyle and Health Considerations
Maintaining a healthy lifestyle can enhance the
effectiveness and safety of TRT for patients looking to get the most from
therapy. Proper diet, regular exercise, adequate sleep, and managing stress
levels all support hormonal health and amplify the benefits of TRT tremendously.
Weight management is essential for good health, as excess body fat can lead to an
increase in estrogen levels, which can counteract the effects of testosterone,
so having a plan in place and support from a medical team can make a tremendous
difference.
A Balanced Perspective on Long-Term TRT Safety
While no medical treatment is without risks, current
research and clinical practices indicate that TRT can be safe and beneficial
when managed correctly. The long-term safety of TRT hinges on a personalized
approach from a doctor who is both knowledgeable and experienced in hormone
therapy, taking into account individual health factors, lifestyle, and specific
treatment goals. By closely monitoring health markers by having regular lab work and
making necessary adjustments over time, the benefits of TRT often outweigh
potential risks for many men.
For men struggling with the effects of low testosterone and
suboptimal androgen deficiency, TRT offers a promising path to regain vitality,
confidence, and quality of life. Long-term use of TRT can be safe when properly
managed by a knowledgeable healthcare provider who keeps a close watchful eye
on critical health indicators. At NovaGenix, we’re committed to providing
high-quality, personalized TRT plans that prioritize both effectiveness and
patient safety with all-inclusive HRT programs for both men and women. If
you’re considering TRT and want to learn more about what long-term therapy
could mean for you, schedule a consultation with us. We offer convenient online
telemedicine appointments for patients. Our team is here to guide you toward
the best choices for your health and well-being.
