NovaGenix Insights

Will Being on TRT Make a Man Sterile? Understanding the effects of testosterone on male fertility and reproductive functioning. We are often asked by men interested in starting TRT the question “Does testosterone therapy cause infertility?” Testosterone replacement therapy in men is a popular therapeutic treatment option for men with low T looking to improve their overall health, wellness, and vitality, but what about its effect on sperm production and fertility in male patients? TRT is often prescribed to address various health concerns in men, with signs and symptoms such as fatigue, low libido , mood swings, decreasing muscle mass and weight gain. Yet there are significant questions and concerns about its impact on male fertility.  While testosterone therapy can provide relief from these and other symptoms associated with low T, (also known as hypogonadism), its effects on male fertility are complex and multifaceted and worth discussing. To understand the relationship betwe...

Understanding Enclomiphene and Its Role in Male Health What is enclomiphene used for in males? Enclomiphene   a medication known for treating infertility in both men and women, holds a distinct place in the treatment landscape. While it's commonly used to stimulate ovulation in women dealing with irregular periods or PCOS, its potential in addressing hypogonadism, a condition marked by insufficient testosterone production in men, is noteworthy. Exploring Enclomiphene: What is Enclomiphene? Enclomiphene citrate, the trans isomer of Clomiphene Citrate ( Clomid . ), primarily gained FDA approval for treating ovarian dysfunction in women. However, off-label use in treating secondary male hypogonadism has been prevalent among physicians for years Hypogonadism arises from inadequate testosterone levels and/or abnormal sperm production due to disruptions in the hypothalamic–pituitary–testicular axis, as noted in The Journal of Clinical Endocrinology & Metabolism. Traditi...

  Choosing Between hCG and Clomid for TRT: Understanding the Options hCG or Clomid. What medication should I be on for TRT? Recent  FDA  regulations have led to increased prescriptions of Clomid for patients undergoing TRT. Clomid, or clomiphene citrate, is a medication utilized by both men and women for similar purposes.  Typically prescribed to women facing ovulation challenges or irregular menstrual cycles,  Clomid   aids fertility by stimulating hormone release to trigger ovulation. In men, Clomid, although off-label, is used to potentially increase testosterone and sperm production by stimulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH).   Patients who need a  prescription of Clomid  will need to get blood work as well as consultation with their physician. Guidelines and Differences: Clomid vs. Enclomiphene What is the difference between Clomid and enclomiphene? Clomiphene citrate and enclomiphene serve...